Laparoscopic Prostate Removal
for Severe, Treatment-Resistant
Chronic Prostatitis


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Physical symptoms, including pain, can be associated with mood dysfunction, including depression. Indeed, pain is among the most important clinical features seen in patients with mood dysfunction. Relief of pain can be associated with a secondary relief of mood dysfunction.

In some cases, treatments for mood dysfunction, including depression, can relieve pain. In other words, the relationship between physical and emotional symptoms can be complex, with one affecting the other. Clearly, emotional turmoil can secondarily amplify the perception of physical symptoms.

There is some evidence that some, but not all, prescription anti-depressant medications have analgesic properties independent of their anti-depressant properties. These properties can be effective in some chronic pain conditions. Among these medications are:

  • Amitriptyline (Tofranil)
  • Nortriptyline (Aventyl)
  • Sertraline (Zoloft)
  • Duloxetine (Cymbalta)
  • Citalopram (Celexa)
As of 2009, a review of the medical literature found that there is little scientific support of the use of these medications in chronic pelvic pain. The specific findings were that:

  • Most of the studies were uncontrolled
  • Amitriptyline may be helpful in interstitial cystitis
  • Nortriptyline, duloxetine, and citalopram should be considerd investigational
  • Medications were generally well tolerated
  • Most studies were of short duration; long term effect and safety cannot be assessed
  • Populations were mixed; some included gynecological pain
As of September, 2010, the National Library of Medicine provides not a single reference for a search for "prostatitis" in combination with any of the anti-depressants listed above. Thus, while these may medications may have a role in treating mood dysfunction associated with clinical prostatitis, there is no scientific basis for their use in treating the symptoms of chronic prostatitis.
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